St. Jude College, a non sectarian institution was established in honor of St. Jude Thaddeus, the Apostle and Patron Saint of the Hopeful and the embodiment of the true Christian spirit. Through its allied health services, it started as a School of Nursing and St. Jude Maternity Clinic in 1950. Face with the growing health needs of the community and the breakthroughs and advances in allied medical sciences, the founders, Dr. Ramon D. Atienza, Jr.and wife, Dr. Felicidad Calip-Atienza, Expanded the Maternity Clinic from a two-storey building to a five-storey building with a 120-bed capacity. Later, they built an eight-storey building to house the growing School of Nursing. The two edifices were inaugurated on the feast day of St. Jude Thaddeus on October 28, 1968. As a result, the Maternity Clinic was elevated to the status of a College for consistently producing outstanding students and exemplary topnotchers in the licensure or board examinations since 1971.

    Through the years, with the sheer dedication and passion of the founders, two additional buildings, both eight- storey high, were erected to comprise the Main Building and High School Building in 1971. by then, baccalaureate courses such as BS in Secretarial Administration, BS in Commerce, BS in Business additional buildings, both eight-storey high, were erected to comprise the Main Building and High School Building in 1971. By then, baccalaureate courses such as BS in Secretarial Administration, BS in Commerce, BS in Business Administration, BS in Nutrition and Dietetics, BS in Nursing and Bachelor of Arts Major in English, Filipino, History and Psychology were already being offered. Further, it had also offered its first masteral course, Masteral in Hospital Administration and two-year associate courses in Junior Secretarial, Dietitian Aide and Health Aide.

     In 1985, government permits were granted to the college to open the following courses: Associate in Hotel and Restaurant and Management, Associate in Radiologic Technology and Master of Arts in Teaching Nursing Education. Graduate courses such as Midwifery, BS in Civil Engineering, BS in Industrial Engineering, Associate in Tourism and BS in Hotel and Restaurant Management were likewise granted their respective government permits in the late 80s. Due to the rapid expansion of academic courses, another eight-storey building was constructed between the existing Main College Building and the Nursing Building in the early 90s. This is presently the College Physical Therapy Building.

     With a vision for a progressive, proactive and dynamic education and the mission of upholding academic and clinical excellence, courses such as BS in Physical Therapy and BS in Computer Science were offered in 1995. Moreover, the masteral programs for Master of Arts in Nursing and Master of Arts Major in Educational Administration were improved.

    Responding to the need to bring quality education to the rural areas, St. Jude College established its first extension at Salitran, Dasmarinas, Cavite. On May 26, 2001, a four-storey building was inaugurated to accommodate college and graduate school students.

     Keeping faith in St. Jude Thaddeus, St. Jude College upholds its vision and mission to advocate quality education with values. The Thaddean student is a global professional in the service of man and for the glory of God.